hosting - What issues would you face if you use Nginx in WordPress

I unfortnately have experience with this but evidently it can be done as these articles and plugins address some of the issues:

• HOWTO: Install WordPress On Nginx
• WordPress + nginx Compatibility Plugin
• Howto nginx + wordpress + ubuntu shortest setup
• Nginx front-end proxy cache for WordPress
• WordPress Pretty Permalinks with Nginx
• WordPress, Nginx and WP Super Cache

Also are you familiar with WP Engine WordPress hosting ? They are evidently using it in a hybrid form with Apache, probably as a front-end proxy.

• Back in Startup Mode… Announcing WP Engine!

Hope these help.